PGT
pre-implantation genetic testing

  • PGTis the technique used for analysing embryos obtained by means of in vitro fertilization to identify genetic abnormalities prior to the embryo transfer.
  • PGT is an effective and accurate method for selecting embryos prior to the embryo transfer.

There are several types of PGT:

  • PGT-A and PGT-SR (PGS) –pre-implantation genetic screening for numeric and structural chromosome abnormalities
  • PGT-M (PGD) – pre-implantation genetic screening for gene abnormalities

An essential step to take before in vitro fertilization

PGT is recommended to be performed during the IVFprocedure for couples with:

1

Several implantation failures

2

Repeated miscarriages

3

A child with a genetic disorder

4

History of inherited genetic disorders in the family

5

Balanced chromosome rearrangements able to be passed on to children in an unbalanced way

6

Advanced maternal age

7

Male infertility

The technique used for the PGTis NGS

PGT benefits:

PGT-Aand PGT-SRallow identifying embryos free of chromosome abnormalities which are appropriate for being implanted.

This selection,performed before the embryo is transferred, is useful because it helps:

  • Increasing the embryo implantation rate
  • Reduce the rate of miscarriages due to foetuses with chromosome abnormalities
  • Reduce the number of IVF cycles
PGT-M is recommended for couples carrying gene-related modifications. This screening helps identify the embryos having inherited the genetic disorder whose carriers are the parents, allowing to implant the healthy ones, and thus reducing the risk of passing on such monogenic genetic disorders within the family.